Internalization mechanisms of cell-penetrating peptides

Cellular Internalization of Quantum Dots Mediated by Cell-Penetrating Peptides

Nanomaterials have been utilized in biomedical applications for many years because of their unique properties such as quantum confinement, surface plasmon resonance, and superparamagnetism. These applications are expected to advance diagnosis and therapeutics. Fluorescent nanomaterials, such as quantum dots (QDs), were exalted in biological imaging and tracking, and trended to replace protein-b...

IMRE MÄGER Characterization of cell-penetrating peptides: assessment of cellular internalization kinetics, mechanisms and bioactivity

Mechanisms of Cellular Uptake of Cell-Penetrating Peptides

Recently, much attention has been given to the problem of drug delivery through the cell-membrane in order to treat and manage several diseases. The discovery of cell penetrating peptides (CPPs) represents a major breakthrough for the transport of large-cargo molecules that may be useful in clinical applications. CPPs are rich in basic amino acids such as arginine and lysine and are able to tra...

Cell-penetrating peptides and bioactive cargoes. Strategies and mechanisms

Cell membrane is an impermeable barrier for most macromolecules. Recently discovered cellpenetrating peptides (CPPs) have gained lot of attention because they can cross the membrane, and, even more, carry cargoes with them. How do CPPs enter the cells is still not clear, while the delivery of different cargoes has been convincingly shown. This thesis concentrates on evaluating CPPs as vectors f...

Cell Penetrating Peptides

During the last ten years it has been observed that a number of peptides and proteins are able to penetrate the cell membrane and enter the cell. Furthermore, it has been shown that even many cargo molecules that are covalently attached to these peptides will be translocated into the cell. Peptides that show the ability to translocate through the cell membrane are usually short peptides of less...